Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 8/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24501494 | 0.96 | POLB (0.47) | POLBGAAALDH1A1HPGDGFER | |
| SCHEMBL22717781 | 0.94 | POLB (0.40) | POLBGAAALDH1A1HPGDGFER | |
| SCHEMBL24501285 | 0.86 | POLB (0.35) | POLBGAAALDH1A1HPGDGFER | |
| SCHEMBL24501049 | 0.85 | DHFR (0.39) | POLBGAAMCHR1SMN1; SMN2GLS | |
| SCHEMBL24500857 | 0.83 | POLB (0.35) | POLBGAAALDH1A1HPGDGFER | |
| SCHEMBL29108540 | 0.82 | FEN1 (0.35) | POLBGAAGLS | |
| SCHEMBL24501232 | 0.82 | KDM5A (0.33) | POLBGAA | |
| SCHEMBL24501428 | 0.81 | POLB (0.33) | POLBGAAMCHR1 | |
| SCHEMBL24500977 | 0.80 | ALDH1A1 (0.35) | POLBGAAALDH1A1HPGDGFER | |
| SCHEMBL24501660 | 0.80 | ALDH1A1 (0.35) | POLBGAAALDH1A1HPGDGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170290815-A1 | GLUTAMINASE INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170290815-A1 | GLUTAMINASE INHIBITORS | GLUL, ASNS, GLS | POLB 2882/4885GAA 142/4885ALDH1A1 959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.