Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2444124 | 0.95 | BRD4 (0.35) | BRD4CREBBPTRPV1TNK2SYK | |
| SCHEMBL2448247 | 0.92 | BRD4 (0.37) | BRD4CREBBPTRPV1SYK | |
| SCHEMBL2450333 | 0.89 | TNK2 (0.38) | BRD4CREBBPTNK2SYK | |
| SCHEMBL2450336 | 0.89 | TNK2 (0.38) | BRD4CREBBPTNK2SYK | |
| SCHEMBL2446870 | 0.86 | ROCK2 (0.36) | BRD4CREBBPTRPV1TNK2SYK | |
| SCHEMBL2450612 | 0.84 | CREBBP (0.41) | BRD4CREBBPTNK2SYK | |
| SCHEMBL2447187 | 0.83 | BRD4 (0.37) | BRD4CREBBPTRPV1SYK | |
| SCHEMBL2451710 | 0.82 | BRD4 (0.35) | BRD4CREBBPTRPV1SYK | |
| SCHEMBL2447102 | 0.80 | CREBBP (0.44) | BRD4CREBBPTRPV1SYK | |
| SCHEMBL2448242 | 0.79 | TNK2 (0.43) | TNK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |