Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 12/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450333 | 1.00 | TNK2 (0.38) | TNK2CHEK1JAK2ABL1LCK | |
| SCHEMBL2444124 | 0.94 | BRD4 (0.35) | TNK2CHEK1JAK2ABL1LCK | |
| SCHEMBL2448242 | 0.91 | TNK2 (0.43) | TNK2CHEK1JAK2ABL1LCK | |
| SCHEMBL2448252 | 0.91 | TNK2 (0.43) | TNK2CHEK1JAK2ABL1LCK | |
| SCHEMBL2450329 | 0.89 | BRD4 (0.32) | TNK2SYKBRD4CREBBP | |
| SCHEMBL2450331 | 0.88 | MAPT (0.34) | TNK2CHEK1JAK2ABL1LCK | |
| SCHEMBL2446870 | 0.85 | ROCK2 (0.36) | TNK2CHEK1JAK2ABL1LCK | |
| SCHEMBL2450612 | 0.84 | CREBBP (0.41) | TNK2SYKBRD4CREBBP | |
| SCHEMBL2449021 | 0.82 | TNK2 (0.49) | TNK2CHEK1JAK2ABL1LCK | |
| SCHEMBL2449020 | 0.82 | TNK2 (0.49) | TNK2CHEK1JAK2ABL1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |