Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28243415 | 0.81 | NR1H4 (0.66) | S1PR1GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL60580 | 0.81 | GRM5 (0.63) | S1PR1GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL66433 | 0.77 | NPC1 (0.64) | GRM5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL16481833 | 0.76 | L3MBTL1 (0.64) | S1PR1GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18950847 | 0.76 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2TP53NFKB1 | |
| SCHEMBL13416504 | 0.75 | S1PR1 (1.00) | S1PR1GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4187017 | 0.75 | GRM5 (1.00) | S1PR1GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22039251 | 0.74 | S1PR1 (0.57) | S1PR1GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18950875 | 0.74 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2TP53NFKB1 | |
| SCHEMBL1114407 | 0.73 | S1PR1 (0.51) | S1PR1GRM5NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889142-B1 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE | PTC THERAPEUTICS INC (US) | 2022-06-15 | — | — | EP | disclosed |