Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 10/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 10/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30545173 | 0.87 | DDB1 (0.46) | DDB1CRBNKDM1ACYP11B2 | |
| SCHEMBL23832682 | 0.86 | DDB1 (0.46) | DDB1CRBNGPR119CYP11B2PRKCG | |
| SCHEMBL24509260 | 0.85 | DDB1 (0.43) | DDB1CRBNGPR119CYP11B2 | |
| SCHEMBL24508323 | 0.84 | CRBN (0.39) | DDB1CRBN | |
| SCHEMBL30545126 | 0.84 | CRBN (0.39) | DDB1CRBN | |
| SCHEMBL29709883 | 0.81 | DDB1 (0.47) | DDB1CRBNGPR119CYP11B2 | |
| SCHEMBL24508841 | 0.81 | DDB1 (0.47) | DDB1CRBNGPR119CYP11B2 | |
| SCHEMBL24508642 | 0.81 | DDB1 (0.42) | DDB1CRBNGPR119KDM1APRMT5 | |
| SCHEMBL24608024 | 0.80 | DDB1 (0.41) | DDB1CRBNGPR119KDM1ACYP11B2 | |
| SCHEMBL31565145 | 0.80 | DDB1 (0.41) | DDB1CRBNGPR119KDM1ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669722-A | Interleukin-1 receptor-related kinase (IRAK) degradants and uses thereof | 凯麦拉医疗公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |