Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445371 | 0.81 | NPSR1 (0.45) | WDR5CYP1A2CYP2D6CYP3A4MAPK1 | |
| SCHEMBL2444689 | 0.77 | CYP1A2 (0.49) | CYP1A2CYP2D6CYP3A4MAPK1CYP2C19 | |
| SCHEMBL2452601 | 0.71 | CYP1A2 (0.37) | CYP1A2CYP2D6CYP3A4MAPK1CYP2C19 | |
| SCHEMBL18939276 | 0.70 | HTT (0.56) | MEN1ALDH1A1KMT2ACNR2TSHR | |
| SCHEMBL2446534 | 0.67 | NPSR1 (0.47) | SCN9AMEN1KMT2AMAPTGAA | |
| SCHEMBL2449017 | 0.66 | CNR2 (0.48) | CYP1A2CYP2D6CYP3A4MAPK1CYP2C19 | |
| SCHEMBL2442786 | 0.66 | MAPT (0.38) | CYP1A2CYP3A4SCN9ACYP2C19MEN1 | |
| SCHEMBL14471486 | 0.65 | CYP1A2 (0.48) | CYP1A2CYP2D6CYP3A4MAPK1CYP2C19 | |
| SCHEMBL4201444 | 0.63 | ALOX15 (0.51) | CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL2450125 | 0.61 | NPSR1 (0.46) | MEN1KMT2AMAPTRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011109587-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-09 | — | — | WO | disclosed |