Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24511675 | 1.00 | DPP4 (0.41) | DPP4ALDH1A1PKMLIPESIGMAR1 | |
| SCHEMBL24517987 | 1.00 | DPP4 (0.41) | DPP4ALDH1A1PKMLIPESIGMAR1 | |
| SCHEMBL30937010 | 0.91 | DPP4 (0.44) | DPP4MCHR1USP30DPP8 | |
| SCHEMBL30937050 | 0.91 | DPP4 (0.44) | DPP4MCHR1USP30DPP8 | |
| SCHEMBL24511505 | 0.85 | DPP4 (0.40) | DPP4ALDH1A1MCHR1DPP8 | |
| SCHEMBL30937160 | 0.80 | MEN1 (0.39) | DPP4LIPEHSD11B1HSD11B2MCHR1 | |
| SCHEMBL28019652 | 0.80 | LIPE (0.44) | ALDH1A1PKMLIPEHSD11B1HSD11B2 | |
| SCHEMBL24518383 | 0.80 | LIPE (0.44) | ALDH1A1PKMLIPEHSD11B1HSD11B2 | |
| SCHEMBL15551380 | 0.80 | LIPE (0.44) | ALDH1A1PKMLIPEHSD11B1HSD11B2 | |
| SCHEMBL30937055 | 0.78 | DPP4 (0.47) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022122876-A1 | N-(IMIDAZO[1,2-B]PYRIDAZIN-3-YL)-1-CYCLOHEXYL-2H-INDAZOLE-5-CARBOXAMIDE AND N-(PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-1-CYCLOHEXYL-2H-INDAZOLE-5-CARBOXAMIDE DERIVATIVES AS IRAK4 INHIBITORS FOR THE TREATMENT OF ASTHMA | ASTRAZENECA AB (SE) | 2022-06-16 | — | — | WO | disclosed |
| US-20220185817-A1 | IRAK4 INHIBITORS | ASTRAZENECA AB (SE) | 2022-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185817-A1 | IRAK4 INHIBITORS | IRAK4, IRAK2, IRAK1 | DPP4 148/4885ALDH1A1 2671/4885PKM 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.