Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CNR2 | P34972 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | BRD2 | P25440 | 1/20 | 0.56 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29717131 | 1.00 | LMNA (0.65) | LMNAMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2927007 | 0.88 | ALDH1A1 (0.66) | LMNAMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL15052643 | 0.84 | ALDH1A1 (0.67) | LMNAALDH1A1SMN1; SMN2L3MBTL1CNR2 | |
| SCHEMBL22433209 | 0.84 | ALDH1A1 (0.69) | LMNAMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL23294420 | 0.83 | KMT2A (0.60) | LMNAMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2080681 | 0.82 | TP53 (0.65) | LMNAMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1592716 | 0.82 | ALDH1A1 (0.61) | LMNAMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL16345591 | 0.82 | LMNA (0.54) | LMNAMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9319918 | 0.82 | ALDH1A1 (0.61) | LMNAMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL841667 | 0.81 | LMNA (0.52) | LMNAMAPTALDH1A1SMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117915903-A | Compounds for the treatment of neurodegenerative, degenerative and metabolic disorders and uses thereof | 佛罗里达大学研究基金会公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2022125989-A1 | COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE, DEGENERATIVE AND METABOLIC DISORDERS | SCRIPPS RESEARCH INSTITUTE, THE (US) | 2022-06-16 | — | — | WO | disclosed |