Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24266819 | 0.72 | KDM4E (0.52) | POLBKDM4ESMN1; SMN2TSHRNPSR1 | |
| SCHEMBL22296045 | 0.69 | POLB (0.54) | POLBKDM4ESMN1; SMN2TSHRNPSR1 | |
| SCHEMBL22561764 | 0.68 | GRM2 (0.52) | POLBKDM4ESMN1; SMN2TSHRNPSR1 | |
| SCHEMBL21654381 | 0.67 | SMN1; SMN2 (0.37) | POLBKDM4ESMN1; SMN2TSHRNPSR1 | |
| SCHEMBL25034321 | 0.67 | POLB (0.51) | POLBKDM4ESMN1; SMN2TSHRNPSR1 | |
| SCHEMBL23586723 | 0.66 | SMN1; SMN2 (0.54) | POLBKDM4ESMN1; SMN2TSHRNPSR1 | |
| Methane SCHEMBL19660217 | 0.65 | POLB (0.52) | POLBKDM4ESMN1; SMN2TSHRNPSR1 | |
| SCHEMBL21651104 | 0.64 | NPSR1 (0.47) | POLBKDM4ESMN1; SMN2TSHRNPSR1 | |
| SCHEMBL23586698 | 0.64 | MAPT (0.51) | POLBKDM4ESMN1; SMN2TSHRNPSR1 | |
| SCHEMBL18926478 | 0.63 | SMN1; SMN2 (0.41) | POLBKDM4ESMN1; SMN2TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022121805-A1 | FUSED RING COMPOUND AS NAV1.8 INHIBITOR AND USE THEREOF | 成都康弘药业集团股份有限公司 | 2022-06-16 | — | — | WO | disclosed |