Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21654381 | 0.94 | SMN1; SMN2 (0.37) | SMN1; SMN2RAB9AKCNMA1ALDH1A1MAPT | |
| SCHEMBL822777 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9AKCNMA1ALDH1A1MAPT | |
| SCHEMBL12204565 | 0.76 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9AKCNMA1ALDH1A1MAPT | |
| SCHEMBL24592756 | 0.74 | HTR6 (0.43) | SMN1; SMN2RAB9A | |
| SCHEMBL12204569 | 0.74 | RAB9A (0.56) | SMN1; SMN2RAB9AKCNMA1ALDH1A1MAPT | |
| SCHEMBL21042484 | 0.73 | KCNMA1 (0.40) | SMN1; SMN2RAB9AKCNMA1ALDH1A1MAPT | |
| SCHEMBL24511925 | 0.73 | MAOA (0.47) | SMN1; SMN2RAB9AKCNMA1TSHRSLC9A1 | |
| SCHEMBL17355202 | 0.73 | TNKS (0.37) | SMN1; SMN2RAB9AKCNMA1ALDH1A1MAPT | |
| SCHEMBL16230166 | 0.73 | TNKS (0.37) | SMN1; SMN2RAB9AKCNMA1ALDH1A1MAPT | |
| SCHEMBL26892187 | 0.73 | TNKS (0.39) | SMN1; SMN2RAB9AKCNMA1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176172-A1 | SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS | Astrazeneca AB (SE) | 2017-06-07 | — | — | EP | disclosed |