Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.53 |
| ▸ | MET | P08581 | 7/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28831506 | 0.84 | KDR (0.53) | KDRMETIGF1RPDGFRAPDGFRB | |
| SCHEMBL20216832 | 0.84 | KDR (0.49) | KDRMETPDGFRAKITSRC | |
| SCHEMBL5208322 | 0.83 | PDGFRB (0.55) | KDRMETPDGFRAPDGFRBFGFR2 | |
| SCHEMBL12663529 | 0.83 | MET (0.40) | KDRMETIGF1RPDGFRAPDGFRB | |
| SCHEMBL5203802 | 0.81 | KDR (0.83) | KDRMETIGF1RPDGFRAPDGFRB | |
| SCHEMBL4471459 | 0.81 | KDR (0.58) | KDRMETIGF1RPDGFRAPDGFRB | |
| SCHEMBL19645596 | 0.80 | KDR (0.84) | KDRMETIGF1RPDGFRAPDGFRB | |
| SCHEMBL19645597 | 0.80 | KDR (0.70) | KDRMETIGF1RPDGFRAPDGFRB | |
| SCHEMBL3968982 | 0.80 | PDGFRA (0.56) | KDRMETPDGFRAPDGFRBKIT | |
| SCHEMBL14098962 | 0.80 | FGFR2 (0.61) | KDRMETPDGFRAPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956138-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | KALA PHARMACEUTICALS INC (US) | 2022-06-22 | — | — | EP | disclosed |