Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19372984 | 0.90 | KDR (0.51) | KDRFLT1EPHA2EPHB4FGFR2 | |
| SCHEMBL19372928 | 0.89 | PDGFRA (0.54) | KDRFGFR2PDGFRAAXLMERTK | |
| SCHEMBL24520223 | 0.84 | KDR (0.53) | KDRFLT1EPHA2EPHB4FGFR2 | |
| SCHEMBL22566436 | 0.81 | MET (0.61) | KDRFGFR2METAXL | |
| SCHEMBL5001922 | 0.80 | AXL (0.53) | KDRMETPDGFRAAXLMERTK | |
| SCHEMBL372090 | 0.80 | AXL (0.76) | KDRFLT1EPHA2METEGFR | |
| SCHEMBL6592222 | 0.79 | KDM1A (0.56) | FGFR2EGFRPDPK1PDGFRA | |
| SCHEMBL10296328 | 0.79 | KDM1A (0.56) | FGFR2EGFRPDPK1PDGFRA | |
| SCHEMBL371747 | 0.79 | MET (0.55) | KDRMETPDGFRAAXLMERTK | |
| SCHEMBL371670 | 0.78 | MET (0.60) | KDRMETPDGFRAAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |