Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781792 | 0.83 | DRD3 (0.54) | NAMPTHTR1ASMN1; SMN2NSD2PABPC1 | |
| SCHEMBL18362307 | 0.83 | NAMPT (0.43) | NAMPTHTR1ASMN1; SMN2NSD2PABPC1 | |
| SCHEMBL3553321 | 0.81 | NAMPT (0.44) | NAMPTHTR1ASMN1; SMN2NSD2PABPC1 | |
| SCHEMBL4905012 | 0.80 | HTR1A (0.54) | NAMPTHTR1ASMN1; SMN2NSD2PABPC1 | |
| SCHEMBL8966405 | 0.80 | — | — | |
| SCHEMBL22030332 | 0.80 | HTR1A (0.42) | NAMPTHTR1ASMN1; SMN2NSD2PABPC1 | |
| SCHEMBL12976558 | 0.79 | DRD3 (0.51) | NAMPTHTR1ASMN1; SMN2NSD2PABPC1 | |
| SCHEMBL22281656 | 0.79 | HSD11B1 (0.51) | NAMPTKDM4EDRD3DRD2 | |
| SCHEMBL15435923 | 0.79 | NAMPT (0.43) | NAMPTHTR1ASMN1; SMN2NSD2PABPC1 | |
| SCHEMBL16507931 | 0.79 | NAMPT (0.43) | NAMPTHTR1ASMN1; SMN2NSD2PABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596072-B1 | PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |