Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 7/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.35 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.35 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.35 |
| ▸ | CBX7 | O95931 | 2/20 | 0.34 |
| ▸ | CDYL2 | Q8N8U2 | 2/20 | 0.34 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18909452 | 0.87 | ACACB (0.42) | JAK2JAK1KDM4ECYP2C9CYP2C19 | |
| SCHEMBL22030477 | 0.84 | FAAH (0.43) | JAK2JAK1KDM4ECYP2C9CYP2C19 | |
| SCHEMBL15998855 | 0.68 | BLM (0.43) | MAPT | |
| SCHEMBL25430636 | 0.67 | RIPK1 (0.46) | — | |
| SCHEMBL17926162 | 0.65 | MYT1 (0.42) | ALDH1A1 | |
| SCHEMBL18724894 | 0.65 | MYT1 (0.42) | CYP2C9ALDH1A1TDP1 | |
| SCHEMBL18909108 | 0.64 | ACACB (0.42) | KDM4ECYP2C9CYP2C19ACHEL3MBTL3 | |
| SCHEMBL20743163 | 0.64 | KDR (0.38) | JAK2KDM4ECYP2C9CYP2C19ACHE | |
| SCHEMBL18909109 | 0.63 | KDM6B (0.40) | ACHE | |
| SCHEMBL30519741 | 0.63 | MAPK1 (0.41) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596072-B1 | PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |