Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.41 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24500534 | 0.81 | DRD3 (0.51) | DRD3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL21281176 | 0.79 | SIGMAR1 (0.40) | DRD3HRH3SIGMAR1MAPT | |
| SCHEMBL25706817 | 0.79 | DRD3 (0.44) | DRD3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL24773181 | 0.78 | HRH2 (0.53) | DRD3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL22521105 | 0.77 | HRH2 (0.56) | DRD3HRH2HRH1BLMMEN1 | |
| SCHEMBL20623216 | 0.76 | GNAI3 (0.41) | HRH2HRH1MEN1KMT2AL3MBTL1 | |
| SCHEMBL5026283 | 0.76 | CACNA2D1 (0.58) | — | |
| SCHEMBL10076105 | 0.76 | DRD3 (0.50) | DRD3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL21423426 | 0.75 | GNAI3 (0.40) | HRH2HRH1MEN1KMT2AL3MBTL1 | |
| SCHEMBL22534819 | 0.75 | GNAI3 (0.40) | HRH2HRH1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596072-B1 | PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |