Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2452177 | 1.00 | PPM1B (0.51) | PPM1BCES2TDP1CHRNA7CHRNB2 | |
| SCHEMBL9172397 | 1.00 | PPM1B (0.51) | PPM1BCES2TDP1CHRNA7CHRNB2 | |
| SCHEMBL20691933 | 0.92 | CES2 (0.49) | PPM1BCES2TDP1CHRNA7CHRNB2 | |
| SCHEMBL13286850 | 0.86 | PPM1B (0.56) | PPM1BCES2TDP1CHRNA7CHRNB2 | |
| SCHEMBL8191270 | 0.85 | PPM1B (0.52) | PPM1BCES2TDP1CHRNA7CHRNB2 | |
| SCHEMBL8183690 | 0.85 | PPM1B (0.52) | PPM1BCES2TDP1CHRNA7CHRNB2 | |
| SCHEMBL13031119 | 0.81 | PPM1B (0.47) | PPM1BCES2TDP1CHRNA7CHRNB2 | |
| SCHEMBL9118362 | 0.81 | ALDH1A1 (0.51) | PPM1BCES2TDP1CHRNA7CHRNB2 | |
| SCHEMBL2023266 | 0.81 | ALDH1A1 (0.51) | PPM1BCES2TDP1CHRNA7CHRNB2 | |
| SCHEMBL2022684 | 0.81 | ALDH1A1 (0.51) | PPM1BCES2TDP1CHRNA7CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273050-B2 | Cyclobutyl purine derivative, angiogenesis promoting agent, lumen formation promoting agent, neurocyte growth promoting agent, and drug | NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY (JP) | 2016-03-01 | — | — | US | disclosed |
| EP-2377865-B1 | CYCLOBUTYL PURINE DERIVATIVE, ANGIOGENESIS PROMOTING AGENT, LUMENIZATION PROMOTING AGENT, NEUROCYTE GROWTH PROMOTING AGENT, AND DRUG | UNIV KAGAWA NAT UNIV CORP (JP) | 2014-12-17 | — | — | EP | disclosed |
| EP-2377865-A1 | CYCLOBUTYL PURINE DERIVATIVE, ANGIOGENESIS PROMOTING AGENT, LUMENIZATION PROMOTING AGENT, NEUROCYTE GROWTH PROMOTING AGENT, AND DRUG | National University Corporation Kagawa University (JP) | 2011-10-19 | — | — | EP | disclosed |
| US-20110230659-A1 | CYCLOBUTYL PURINE DERIVATIVE, ANGIOGENESIS PROMOTING AGENT, LUMEN FORMATION PROMOTING AGENT, NEUROCYTE GROWTH PROMOTING AGENT, AND DRUG | NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY (JP) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230659-A1 | CYCLOBUTYL PURINE DERIVATIVE, ANGIOGENESIS PROMOTING AGENT, LUMEN FORMATION PROMOTING AGENT, NEUROCYTE GROWTH PROMOTING AGENT, AND DRUG | DCX, MKI67, SLC29A1 | PPM1B 2945/4885CES2 3168/4885TDP1 786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.