Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145360 | 0.98 | DGAT1 (0.84) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12313853 | 0.91 | DGAT1 (0.97) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12299380 | 0.90 | DGAT1 (0.82) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12299836 | 0.90 | DGAT1 (0.72) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2452258 | 0.90 | DGAT1 (0.85) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12300650 | 0.90 | DGAT1 (1.00) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12299828 | 0.90 | DGAT1 (1.00) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12300652 | 0.89 | DGAT1 (0.81) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12313702 | 0.89 | DGAT1 (0.77) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2393035 | 0.89 | DGAT1 (1.00) | DGAT1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716312-B2 | Inhibitors of diacylglycerol acyltransferase | MERCK SHARP & DOHME CORPORATION (US) | 2014-05-06 | — | — | US | disclosed |
| EP-2367598-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Schering Corporation (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010059602-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-05-27 | — | — | WO | disclosed |