SCHEMBL2452184

SCHEMBL2452184

N#Cc1cccc(Nc2cc(F)c(Cl)c(Sc3ccccc3)c2)c1C#N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.37
ALDH1A1 P00352 3/20 0.37
MAPT P10636 3/20 0.37
HPGD P15428 3/20 0.37
ABCC9 O60706 1/20 0.37
ABCC8 Q09428 1/20 0.37
KCNJ11 Q14654 1/20 0.37
KCNJ8 Q15842 1/20 0.37
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
LRRK2 Q5S007 1/20 0.34
PGR P06401 1/20 0.33
AR P10275 1/20 0.33
MEN1 O00255 4/20 0.33
KMT2A Q03164 4/20 0.33
CYP1A2 P05177 3/20 0.33
CYP2C19 P33261 3/20 0.33
GAA P10253 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP3A4 P08684 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2453559 0.89 KDM4E (0.39) KDM4EALDH1A1MAPTHPGDABCC9
SCHEMBL2453616 0.88 KDM4E (0.38) KDM4EALDH1A1MAPTHPGDABCC9
SCHEMBL2458103 0.79 HSD11B1 (0.34) KDM4EALDH1A1MAPTLRRK2PGR
SCHEMBL2451810 0.78 HSD11B1 (0.34) KDM4EALDH1A1MAPTLRRK2PGR
SCHEMBL2458731 0.77 MAPT (0.39) KDM4EALDH1A1MAPTHPGDMAOB
SCHEMBL6218942 0.76 KDM4E (0.39) KDM4EALDH1A1MAPTHPGDMAOB
SCHEMBL2457570 0.74 TAS1R3 (0.37) KDM4EALDH1A1LRRK2GAAALOX15
SCHEMBL2456522 0.72 HSD11B1 (0.35) KDM4EALDH1A1MAPTHPGDLRRK2
SCHEMBL2460050 0.72 MAPT (0.45) KDM4EALDH1A1MAPTHPGDMAOB
SCHEMBL2454722 0.70 JAK1 (0.36) KDM4EALDH1A1MAPTHPGDMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1577350-B1 Method for production of halogen-containing phthalocyanine compound NIPPON CATALYTIC CHEM IND (JP) 2011-09-14 EP disclosed
EP-1577350-A1 Method for production of halogen-containing phthalocyanine compound Nippon Shokubai Co., Ltd. (JP) 2005-09-21 EP disclosed