Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22878453 | 0.85 | HIF1A (0.41) | SIGMAR1HRH3HIF1AEPAS1HTR2A | |
| SCHEMBL28885908 | 0.83 | GRM2 (0.45) | SIGMAR1HRH3GRM2JAK2TLR7 | |
| SCHEMBL12176281 | 0.83 | ALDH1A1 (0.51) | SIGMAR1HRH3 | |
| SCHEMBL25181316 | 0.83 | PRMT6 (0.45) | HRH3GRM2JAK2TLR7CYP3A4 | |
| SCHEMBL3400443 | 0.83 | ALDH1A1 (0.53) | HRH3GRM2JAK2TLR7 | |
| SCHEMBL3992623 | 0.82 | CYP3A4 (0.56) | SIGMAR1HIF1ACYP3A4HSD17B10 | |
| Hydrochloric Acid SCHEMBL25412712 | 0.81 | CYP3A4 (0.54) | SIGMAR1HIF1ACYP3A4HSD17B10 | |
| SCHEMBL12074618 | 0.80 | ALDH1A1 (0.48) | HRH3GRM2JAK2TLR7FAAH | |
| SCHEMBL25184780 | 0.79 | USP2 (0.58) | HIF1ACYP3A4HSD17B10KDM1A | |
| SCHEMBL2558372 | 0.79 | HRH3 (0.40) | HRH3GRM2JAK2TLR7KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4015504-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |