Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29558535 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1POLBGAAMAPK1 | |
| SCHEMBL17976536 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1POLBGAAMAPK1 | |
| SCHEMBL17971692 | 0.88 | HTR7 (0.39) | KDM4EALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL29558147 | 0.88 | HTR7 (0.39) | KDM4EALDH1A1MAPK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29616809 | 0.87 | HTR7 (0.39) | KDM4EALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL17971681 | 0.87 | GFER (0.43) | KDM4EALDH1A1MAPK1TDP1MEN1 | |
| SCHEMBL17957470 | 0.87 | RARA (0.42) | ALDH1A1MAPK1HDAC3HDAC2HDAC8 | |
| SCHEMBL17957468 | 0.87 | RARA (0.42) | ALDH1A1MAPK1HDAC3HDAC2HDAC8 | |
| SCHEMBL17971686 | 0.86 | KDM4E (0.38) | KDM4EALDH1A1POLBGAAMEN1 | |
| Hydrochloric Acid SCHEMBL29616828 | 0.86 | GFER (0.43) | KDM4EALDH1A1MAPK1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4015514-A1 | 3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS | Valo Health, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |