SCHEMBL2452397

SCHEMBL2452397

CC(C)C1CC(Oc2ccn(-c3ccc(S(C)(=O)=O)cc3)c(=O)c2)CCN1C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 19/20 0.64
MCHR1 Q99705 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2452868 0.95 GPR119 (0.63) GPR119MCHR1
SCHEMBL2454637 0.90 GPR119 (0.52) GPR119
SCHEMBL2458824 0.88 GPR119 (0.54) GPR119
SCHEMBL2452245 0.88 GPR119 (0.48) GPR119MCHR1
SCHEMBL1549888 0.88 GPR119 (0.64) GPR119MCHR1
SCHEMBL2453891 0.86 GPR119 (0.47) GPR119MCHR1
SCHEMBL2454667 0.86 GPR119 (0.62) GPR119MCHR1
SCHEMBL2458838 0.86 GPR119 (0.46) GPR119MCHR1
SCHEMBL2452825 0.85 GPR119 (0.64) GPR119MCHR1
SCHEMBL2450627 0.85 GPR119 (0.51) GPR119MCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2170864-B1 PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2011-09-14 EP claimed