Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595399 | 1.00 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1CYP2C19LMNA | |
| SCHEMBL2105387 | 1.00 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1CYP2C19LMNA | |
| SCHEMBL25774613 | 1.00 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1CYP2C19LMNA | |
| SCHEMBL2105390 | 1.00 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1CYP2C19LMNA | |
| SCHEMBL18778760 | 0.91 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1CYP2C19LMNA | |
| SCHEMBL14916561 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1GAAUSP2 | |
| SCHEMBL26629419 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1GAAUSP2 | |
| SCHEMBL25484796 | 0.84 | ALDH1A1 (0.48) | ALDH1A1KMT2ALMNAL3MBTL1GAA | |
| SCHEMBL10258854 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1L3MBTL1PKM | |
| SCHEMBL9749200 | 0.81 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1L3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133345-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-06-23 | — | — | WO | disclosed |