Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.31 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23334546 | 0.90 | MAPT (0.42) | MAPTRAB9AHTTPOLBKDR | |
| SCHEMBL10265072 | 0.80 | MAPT (0.42) | MAPTRAB9APOLBKDRCHRNB2 | |
| SCHEMBL6741043 | 0.80 | MAPT (0.49) | MAPTRAB9AHTTPOLBKDR | |
| SCHEMBL4525335 | 0.76 | ALDH1A1 (0.49) | MAPTRAB9AHTTPOLBSMN1; SMN2 | |
| SCHEMBL2791587 | 0.74 | MAPT (0.39) | MAPTRAB9APOLBKDRCHRNB2 | |
| SCHEMBL1099100 | 0.70 | RAB9A (0.45) | MAPTRAB9APOLBSMN1; SMN2 | |
| SCHEMBL16230053 | 0.70 | MAPT (0.40) | MAPTRAB9AHTTPOLBALDH3A1 | |
| SCHEMBL21640132 | 0.70 | MAPT (0.36) | MAPTRAB9APOLBKDRCHRNB2 | |
| SCHEMBL14933939 | 0.68 | TLR9 (0.37) | MAPTRAB9AHTTPOLBTLR9 | |
| SCHEMBL30116117 | 0.67 | MAPT (0.38) | MAPTRAB9AHTTPOLBTLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133215-A1 | CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS INCORPORATED (US) | 2022-06-23 | — | — | WO | disclosed |