Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24528856 | 0.82 | KDM4E (0.36) | KMT2AMEN1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL24528859 | 0.78 | AAK1 (0.39) | SMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL24528858 | 0.76 | BCL2A1 (0.39) | ALDH1A1L3MBTL1HTTNPC1MAPT | |
| SCHEMBL24528864 | 0.75 | BCL2A1 (0.43) | ALDH1A1L3MBTL1HTTNPC1MAPT | |
| SCHEMBL24528855 | 0.73 | ALDH1A1 (0.42) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL24120195 | 0.69 | HPGD (0.61) | L3MBTL3KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19670980 | 0.68 | ALDH1A1 (0.73) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL16823464 | 0.67 | MEN1 (0.71) | KMT2AMEN1ABL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16845160 | 0.66 | MEN1 (0.55) | KMT2AMEN1ABL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16845139 | 0.66 | MEN1 (0.51) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |