Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24528855 | 0.89 | ALDH1A1 (0.42) | KDM4EHRH3ACHEBCHEALDH1A1 | |
| SCHEMBL24528848 | 0.82 | L3MBTL3 (0.40) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL24528859 | 0.77 | AAK1 (0.39) | SMN1; SMN2BCL2A1 | |
| SCHEMBL24528858 | 0.75 | BCL2A1 (0.39) | KDM4EALDH1A1HTTBCL2A1 | |
| SCHEMBL24528864 | 0.74 | BCL2A1 (0.43) | ALDH1A1HTTBCL2A1 | |
| SCHEMBL18173436 | 0.73 | KDM1A (0.46) | KDM4EHRH3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2238595 | 0.68 | ALDH1A1 (0.47) | KDM4EHRH3ACHEBCHEALDH1A1 | |
| SCHEMBL24881010 | 0.68 | KCNH2 (0.48) | KDM4EALDH1A1KCNH2 | |
| SCHEMBL24881009 | 0.68 | CHRM2 (0.51) | KDM4EALDH1A1KCNH2 | |
| SCHEMBL803672 | 0.67 | SIGMAR1 (0.59) | ACHEBCHEKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116897150-A | Novel bifunctional molecules for protein-targeted degradation | 安菲斯塔治疗有限公司 | 2023-10-17 | — | — | CN | disclosed |
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |