Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529289 | 0.84 | HCRTR2 (0.35) | HCRTR2KDM4EHPGDNPSR1SUV39H2 | |
| SCHEMBL24387354 | 0.82 | HCRTR2 (0.34) | HCRTR2SUV39H2DYRK1A | |
| SCHEMBL24387355 | 0.80 | HCRTR2 (0.34) | HCRTR2 | |
| SCHEMBL2211698 | 0.75 | DHODH (0.44) | KDM4EHPGDNPSR1MITFLMNA | |
| SCHEMBL2876715 | 0.73 | PLCG1 (0.43) | KDM4EHPGDNPSR1LMNAMEN1 | |
| SCHEMBL2881702 | 0.72 | KDM4E (0.45) | KDM4EHPGDNPSR1LMNADYRK1A | |
| SCHEMBL24529459 | 0.69 | HCRTR2 (0.35) | HCRTR2MEN1KMT2A | |
| SCHEMBL2214323 | 0.68 | ALDH1A1 (0.41) | KDM4EHPGDNPSR1LMNAHTT | |
| SCHEMBL2209412 | 0.68 | ABL1 (0.41) | KDM4EHPGDNPSR1LMNAHTT | |
| SCHEMBL2214081 | 0.68 | SCD (0.42) | KDM4EHPGDNPSR1LMNASTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262788-A1 | UREA OREXIN RECEPTOR AGONISTS | Merck Sharp & Dohme LLC (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |