Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.31 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529251 | 0.81 | HCRTR2 (0.36) | HCRTR2CD274PDCD1LG2 | |
| SCHEMBL24529160 | 0.81 | HCRTR2 (0.49) | HCRTR2 | |
| SCHEMBL24529426 | 0.80 | HCRTR2 (0.41) | HCRTR2TLR9TLR8TLR7ACVR2A | |
| SCHEMBL27181057 | 0.77 | HCRTR2 (0.43) | HCRTR2 | |
| SCHEMBL27181053 | 0.77 | HCRTR2 (0.43) | HCRTR2 | |
| SCHEMBL24386989 | 0.72 | HCRTR2 (0.41) | HCRTR2 | |
| SCHEMBL24529233 | 0.71 | HCRTR2 (0.41) | HCRTR2TLR9TLR8TLR7PIK3CD | |
| SCHEMBL24387010 | 0.70 | HCRTR2 (0.34) | HCRTR2 | |
| SCHEMBL24387056 | 0.69 | HCRTR2 (0.34) | HCRTR2TLR9TLR8TLR7 | |
| SCHEMBL29749845 | 0.68 | HCRTR2 (0.37) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |