Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.73 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12303457 | 0.84 | KDR (1.00) | KDRRET | |
| SCHEMBL2455241 | 0.84 | KDR (1.00) | KDRRET | |
| SCHEMBL2453636 | 0.82 | KDR (0.76) | KDRRET | |
| SCHEMBL2447882 | 0.78 | KDR (0.74) | KDRRETDRD1TRPA1 | |
| SCHEMBL2454635 | 0.71 | KDR (0.74) | KDRRET | |
| SCHEMBL14414571 | 0.70 | KDR (0.76) | KDRRET | |
| SCHEMBL12303498 | 0.68 | KDR (1.00) | KDRRET | |
| SCHEMBL2456687 | 0.68 | KDR (1.00) | KDRRET | |
| SCHEMBL2456690 | 0.68 | KDR (1.00) | KDRRET | |
| SCHEMBL2451345 | 0.68 | KDR (0.43) | KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013153-B2 | Substituted pyrimidine kinase inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-09-06 | — | — | US | disclosed |
| US-7297747-B2 | Polymerization process and polymer composition | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-11-20 | — | — | US | disclosed |
| US-20070254896-A1 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-11-01 | — | — | US | disclosed |
| WO-2007109783-A2 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-09-27 | — | — | WO | disclosed |
| US-7122498-B2 | Metallocenes and catalyst compositions derived therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2006-10-17 | — | — | US | disclosed |
| US-6870016-B1 | Polymerization process and polymer composition | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2005-03-22 | — | — | US | disclosed |
| US-20050059785-A1 | Polymerization process and polymer composition | HART JAMES R (US) | 2005-03-17 | — | — | US | disclosed |
| US-20050054520-A1 | Metallocenes and catalyst compositions derived therefrom | EXXONMOBIL CHEMICAL PATENT INC. | 2005-03-10 | — | — | US | disclosed |
| EP-1421090-A2 | METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM | Exxonmobil Chemical Patents Inc. (US) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003002583-A2 | METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254896-A1 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | DTYMK, TK1, DCK | KDR 1975/4885RET 577/4885DRD1 4754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.