Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27181178 | 1.00 | ALDH1A1 (0.43) | ALDH1A1MAOBMAOAKDM1ARCOR1 | |
| SCHEMBL13888944 | 0.77 | MAOB (0.50) | ALDH1A1MAOBMAOAKDM1AMEN1 | |
| SCHEMBL12188964 | 0.77 | MAOB (0.50) | ALDH1A1MAOBMAOAKDM1AMEN1 | |
| SCHEMBL26933019 | 0.76 | MAOB (0.53) | ALDH1A1MAOBMAOAKDM1AMEN1 | |
| SCHEMBL24529203 | 0.74 | MAOB (0.41) | ALDH1A1MAOBMAOAKDM1ARCOR1 | |
| SCHEMBL24529194 | 0.74 | KDM1A (0.40) | ALDH1A1MAOBMAOAKDM1ARCOR1 | |
| SCHEMBL27179769 | 0.74 | MAOB (0.41) | ALDH1A1MAOBMAOAKDM1ARCOR1 | |
| SCHEMBL24529187 | 0.74 | KDM1A (0.40) | ALDH1A1MAOBMAOAKDM1ARCOR1 | |
| SCHEMBL4337820 | 0.72 | MEN1 (0.63) | ALDH1A1MAOBMAOAKDM1AMEN1 | |
| SCHEMBL27771288 | 0.72 | MAOA (0.47) | ALDH1A1MAOBMAOAKDM1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |