Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.81 |
| ▸ | TP53 | P04637 | 2/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357637 | 0.86 | CYP3A4 (0.61) | TSHRTP53CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL24533635 | 0.85 | CYP3A4 (0.60) | TSHRTP53CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL24533663 | 0.81 | USP2 (0.60) | TSHRTP53CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18568687 | 0.79 | CYP3A4 (0.54) | TSHRTP53CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3867743 | 0.79 | KMT2A (0.59) | TSHRTP53CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12024152 | 0.79 | HTT (0.58) | TSHRTP53CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2354757 | 0.78 | KMT2A (0.58) | TSHRTP53CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3870979 | 0.76 | KMT2A (0.58) | TSHRTP53CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3866576 | 0.75 | TSHR (0.55) | TSHRTP53CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3872757 | 0.74 | TSHR (0.60) | TSHRTP53CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133237-A2 | METHODS OF TREATING NEURODEGENERATIVE DISORDERS AND STAT3-LINKED CANCERS USING SUPPRESSORS OF ELECTRON LEAK | CORNELL UNIVERSITY (US) | 2022-06-23 | — | — | WO | disclosed |