Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL4282132 | 1.00 | — | — | |
| Guanidine SCHEMBL29088714 | 1.00 | NOS2 (0.39) | — | |
| Guanidine SCHEMBL5053878 | 1.00 | NOS2 (0.39) | — | |
| Guanidine SCHEMBL28377118 | 1.00 | NOS2 (0.39) | — | |
| Guanidine SCHEMBL8024162 | 1.00 | — | — | |
| Guanidine SCHEMBL17184362 | 1.00 | NOS2 (0.39) | — | |
| Guanidine SCHEMBL3349156 | 1.00 | — | — | |
| Guanidine SCHEMBL19610646 | 1.00 | NOS2 (0.39) | — | |
| Guanidine SCHEMBL395351 | 1.00 | NOS2 (0.39) | — | |
| Guanidine SCHEMBL28140556 | 1.00 | NOS2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113293456-A | Preparation method of polyvinyl chloride guanidine hydrochloride electrostatic fiber and mask containing antibacterial fiber | 吉林师范大学 | 2021-08-24 | — | — | CN | claimed |
| WO-2019180519-A1 | METHOD AND KIT FOR ISOLATION OF NUCLEIC ACIDS FROM A SAMPLE | METAGENOM BIO HOLDINGS PTE LTD. (SG) | 2019-09-26 | — | — | WO | claimed |
| CN-107190344-B | A kind of manufacturing method of polyvinyl chloride guanidine hydrochloride anti-bacterial fibre | 吉林师范大学 | 2019-06-07 | — | — | CN | claimed |
| CN-107190344-A | A kind of manufacture method of polyvinyl chloride guanidine hydrochloride anti-bacterial fibre | 吉林师范大学 | 2017-09-22 | — | — | CN | claimed |
| CN-105646467-A | Anticancer compound osimertinib and synthesis method thereof | 黄燕鸽 | 2016-06-08 | — | — | CN | claimed |
| CN-1729172-A | Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity | SIGMA TAU IND FARMACEUTI (IT) | 2006-02-01 | — | — | CN | claimed |
| US-20260092310-A1 | CAS12A COMPOSITIONS AND METHODS | NEW ENGLAND BIOLABS, INC. (US) | 2026-04-02 | — | — | US | disclosed |
| US-20250026742-A1 | COMPOUND AS ATR KINASE INHIBITOR | SUZHOU ARK BIOPHARMACEUTICAL CO., LTD. (CN) | 2025-01-23 | — | — | US | disclosed |
| CN-115703768-B | Compounds useful as inhibitors of ATR kinase | 苏州爱科百发生物医药技术有限公司 | 2024-12-17 | — | — | CN | disclosed |
| EP-3889158-B1 | FUSED [1,2]IMIDAZO[4,5-C] RING COMPOUNDS SUBSTITUTED WITH GUANIDINO GROUPS | SOLVENTUM INTELLECTUAL PROPERTIES COMPANY (US) | 2024-07-03 | — | — | EP | disclosed |
| CN-118020822-A | Preparation method and application of freeze-dried powder of unfrozen myoplasma enzymatic hydrolysate for fresh-keeping of frozen meat | 北京工商大学 | 2024-05-14 | — | — | CN | disclosed |
| CN-117897478-A | Novel microbial diamine oxidase derived from yarrowia lipolytica for biogenic amine degradation | 霍恩海姆大学 | 2024-04-16 | — | — | CN | disclosed |
| CN-117770304-A | Preparation method of polyelectrolyte type nanoemulsion for fresh-keeping of frozen meat and ice coating method thereof | 北京工商大学 | 2024-03-29 | — | — | CN | disclosed |
| CN-1077193-A | N-5 position-protected 2,5-diamino-4,6-dichloro pyrimidine and production method thereof | LONZA AG (CH) | 1993-10-13 | — | — | CN | disclosed |
| EP-0271211-B1 | USE OF CARTILAGE-INDUCING FACTOR B (CIF-B) FOR THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING TUMOR GROWTH | CELTRIX PHARMACEUTICALS, INC. (US) | 1992-08-19 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0271211-A2 | Use of cartilage-inducing factor B (cif-B) for the manufacture of a medicament for inhibiting tumor growth | CELTRIX PHARMACEUTICALS, INC. (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4707478-A | ANTIPROTOZOA AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| US-4129657-A | Imidazole guanidines and use as inhibitors of histamine activity | SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-12-12 | — | — | US | disclosed |