Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 12/20 | 0.60 |
| ▸ | NOD2 | Q9HC29 | 8/20 | 0.60 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20564620 | 0.90 | RIPK2 (0.62) | RIPK2NOD2ACVR1FGFR1EPHB4 | |
| SCHEMBL20564698 | 0.84 | RIPK2 (0.62) | RIPK2NOD2ACVR1MAP3K5SYK | |
| SCHEMBL31006394 | 0.84 | RIPK2 (0.62) | RIPK2NOD2ACVR1MAP3K5SYK | |
| SCHEMBL20564621 | 0.83 | BRAF (0.53) | RIPK2NOD2ACVR1FGFR1EPHB4 | |
| SCHEMBL20564627 | 0.82 | ACVR1 (0.49) | RIPK2NOD2ACVR1FGFR1EPHB4 | |
| SCHEMBL29498182 | 0.81 | RIPK2 (0.49) | RIPK2NOD2ACVR1FGFR1EPHB4 | |
| SCHEMBL20563558 | 0.81 | RIPK2 (0.49) | RIPK2NOD2ACVR1FGFR1EPHB4 | |
| SCHEMBL18376612 | 0.81 | RIPK2 (0.61) | RIPK2NOD2ACVR1FGFR1EPHB4 | |
| SCHEMBL20563968 | 0.75 | RIPK2 (1.00) | RIPK2NOD2ACVR1FGFR4FGFR1 | |
| SCHEMBL29498214 | 0.75 | RIPK2 (1.00) | RIPK2NOD2ACVR1FGFR4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220194937-A1 | PROTEIN KINASE INHIBITORS AND USES THEREOF FOR THE TREATMENT OF DISEASES AND CONDITIONS | UNIVERSITY OF HOUSTON SYSTEM | 2022-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220194937-A1 | PROTEIN KINASE INHIBITORS AND USES THEREOF FOR THE TREATMENT OF DISEASES AND CONDITIONS | RIPK2, RIPK1, RIPK4 | RIPK2 1/4885NOD2 295/4885ACVR1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.