Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 13/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | IKBKB | O14920 | 4/20 | 0.61 |
| ▸ | CHUK | O15111 | 4/20 | 0.61 |
| ▸ | AKT1 | P31749 | 4/20 | 0.61 |
| ▸ | AKT2 | P31751 | 4/20 | 0.61 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.61 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245342 | 1.00 | PADI4 (0.68) | PADI4MAPK10IKBKBCHUKAKT1 | |
| SCHEMBL16111883 | 0.91 | PADI4 (0.68) | PADI4MAPK10IKBKBCHUKAKT1 | |
| SCHEMBL16111884 | 0.91 | PADI4 (0.68) | PADI4MAPK10IKBKBCHUKAKT1 | |
| SCHEMBL243968 | 0.89 | PADI4 (0.68) | PADI4MAPK10IKBKBCHUKAKT1 | |
| SCHEMBL243969 | 0.89 | PADI4 (0.68) | PADI4MAPK10IKBKBCHUKAKT1 | |
| SCHEMBL6493833 | 0.88 | PADI4 (0.81) | PADI4MAPK10IKBKBCHUKAKT1 | |
| SCHEMBL6493835 | 0.88 | PADI4 (0.81) | PADI4MAPK10IKBKBCHUKAKT1 | |
| SCHEMBL23498282 | 0.87 | MAPK10 (0.81) | PADI4MAPK10IKBKBCHUKAKT1 | |
| SCHEMBL6479414 | 0.87 | PADI4 (0.67) | PADI4MAPK10IKBKBCHUKAKT1 | |
| SCHEMBL6479411 | 0.87 | PADI4 (0.67) | PADI4MAPK10IKBKBCHUKAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2716285-B9 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT DE LA RECH SCIENT -CNRS- (FR) | 2017-03-01 | — | — | EP | claimed |
| EP-2716285-B1 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT RECH SCIENT (FR) | 2016-04-27 | — | — | EP | claimed |
| JP-2012500393-A | — | — | 2012-01-05 | — | — | JP | claimed |
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2011-09-01 | — | — | US | claimed |
| EP-2331967-A2 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASES ASSOCIATED WITH BONE LOSS | Centre National de la Recherche Scientifique (C.N.R.S) (FR) | 2011-06-15 | — | — | EP | claimed |
| WO-2010020647-A2 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2010-02-25 | — | — | WO | claimed |
| EP-2716285-B9 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT DE LA RECH SCIENT -CNRS- (FR) | 2017-03-01 | — | — | EP | disclosed |
| EP-2716285-B1 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT RECH SCIENT (FR) | 2016-04-27 | — | — | EP | disclosed |
| EP-2331967-B1 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASES ASSOCIATED WITH BONE LOSS | CENTRE NAT RECH SCIENT (FR) | 2015-11-04 | — | — | EP | disclosed |
| US-9091678-B2 | Method for identifying compounds useful for treating and/or preventing disease-associated bone loss | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2015-07-28 | — | — | US | disclosed |
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2011-09-01 | — | — | US | disclosed |
| EP-2331967-A2 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASES ASSOCIATED WITH BONE LOSS | Centre National de la Recherche Scientifique (C.N.R.S) (FR) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010020647-A2 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | DOCK5, ARHGDIB, ARHGDIA | PADI4 2230/4885MAPK10 756/4885IKBKB 2657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.