SCHEMBL24534409

SCHEMBL24534409

Clc1ccc(-c2cccnc2-c2ccccc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 2/20 0.59
PTGS1 P23219 1/20 0.59
KDM4E B2RXH2 1/20 0.52
LMNA P02545 1/20 0.52
GAA P10253 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
CYP1A2 P05177 1/20 0.50
CCNA2 P20248 1/20 0.48
CDK2 P24941 1/20 0.48
MAP4K4 O95819 1/20 0.46
ALDH1A2 O94788 1/20 0.45
ALDH1A3 P47895 1/20 0.45
FEN1 P39748 1/20 0.45
TDP1 Q9NUW8 1/20 0.44
ALDH1A1 P00352 1/20 0.44
HTT P42858 1/20 0.44
HSD17B10 Q99714 1/20 0.44
IDO1 P14902 1/20 0.43
TDO2 P48775 1/20 0.43
CYP3A4 P08684 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28279884 0.94 PTGS2 (0.51) PTGS2PTGS1KDM4ELMNAGAA
SCHEMBL37278 0.88 PTGS2 (0.66) PTGS2PTGS1GAAFEN1TDP1
SCHEMBL30021842 0.86 PTGS2 (0.64) PTGS2PTGS1GAAFEN1TDP1
Ammonia Solution, Strong SCHEMBL20599554 0.86 PTGS2 (0.64) PTGS2PTGS1GAAFEN1TDP1
Phosphine SCHEMBL29108837 0.86 PTGS2 (0.64) PTGS2PTGS1GAAFEN1TDP1
SCHEMBL29227428 0.86 PTGS2 (0.64) PTGS2PTGS1GAAFEN1TDP1
SCHEMBL3344343 0.86 PTGS2 (0.64) PTGS2PTGS1GAAFEN1TDP1
SCHEMBL18449665 0.86 PTGS2 (0.45) PTGS2PTGS1KDM4EGAACYP1A2
SCHEMBL18448915 0.86 PTGS2 (0.45) PTGS2PTGS1KDM4EGAACYP1A2
Hydrazine SCHEMBL29197518 0.84 PTGS2 (0.62) PTGS2PTGS1GAAMAP4K4FEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022131135-A1 PYRIMIDINE COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT 東ソー株式会社 2022-06-23 WO disclosed
WO-2022131135-A1 PYRIMIDINE COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT 東ソー株式会社 2022-06-23 WO disclosed