Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16559346 | 0.90 | KLKB1 (0.36) | PTGER1KLKB1NPC1DGAT1KDM4E | |
| SCHEMBL24537118 | 0.87 | NPC1 (0.40) | KLKB1NPC1DGAT1KDM4E | |
| SCHEMBL24537117 | 0.85 | ALDH1A1 (0.40) | NPC1DGAT1KDM4EMAPT | |
| SCHEMBL30630545 | 0.84 | NPC1 (0.41) | PTGER1KLKB1NPC1DGAT1KDM4E | |
| SCHEMBL29601443 | 0.83 | KMT2A (0.39) | PTGER1KLKB1NPC1DGAT1MEN1 | |
| SCHEMBL15555261 | 0.83 | KMT2A (0.36) | KLKB1NPC1DGAT1KDM4EMEN1 | |
| SCHEMBL16445794 | 0.81 | POLB (0.33) | PTGER1KLKB1NPC1DGAT1 | |
| SCHEMBL28851116 | 0.80 | PTGER1 (0.39) | PTGER1KDM4EMAPTMEN1USP2 | |
| SCHEMBL4016651 | 0.80 | ALDH1A1 (0.43) | NPC1MAPTMEN1HPGDKMT2A | |
| SCHEMBL20028437 | 0.80 | NPC1 (0.37) | NPC1DGAT1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262807-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| CN-116829151-A | Azaquinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |