Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19926085 | 0.86 | KMT2A (0.49) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL24537124 | 0.83 | PTGER1 (0.39) | KMT2AMEN1NPC1DGAT1PTGER1 | |
| SCHEMBL30162854 | 0.80 | KMT2A (0.41) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL28851116 | 0.80 | PTGER1 (0.39) | KMT2AMEN1ALDH1A1PTGER1 | |
| SCHEMBL24719220 | 0.78 | SMN1; SMN2 (0.51) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL28851114 | 0.78 | NPC1 (0.53) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL5248123 | 0.77 | ALDH1A1 (0.41) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL16559346 | 0.75 | KLKB1 (0.36) | KMT2AMEN1NPC1ALDH1A1DGAT1 | |
| SCHEMBL18074464 | 0.73 | SMN1; SMN2 (0.39) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL24537117 | 0.73 | ALDH1A1 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115109061-A | Tricyclic compounds | 北京加科思新药研发有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-112513041-B | Tricyclic compounds | 北京加科思新药研发有限公司 | 2022-05-10 | — | — | CN | disclosed |