Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10155572 | 0.93 | TRPM8 (0.47) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL29112383 | 0.90 | TRPM8 (0.47) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL24540494 | 0.90 | TRPM8 (0.47) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL24540793 | 0.90 | TRPM8 (0.47) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL2628625 | 0.89 | TRPM8 (0.49) | TRPM8EPHX1ALDH1A1HPGDTAAR1 | |
| SCHEMBL890905 | 0.89 | TRPM8 (0.43) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL13465384 | 0.89 | TRPM8 (0.43) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL10155564 | 0.89 | TRPM8 (0.43) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL24540531 | 0.88 | TRPM8 (0.46) | TRPM8EPHX1P2RX4SIGMAR1TRPV1 | |
| SCHEMBL24540387 | 0.88 | TRPM8 (0.48) | TRPM8EPHX1P2RX4SIGMAR1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133027-A1 | SUBSTITUTED CYCLOHEXANECARBOXAMIDES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-06-23 | — | — | WO | disclosed |