Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10155564 | 1.00 | TRPM8 (0.43) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL13465384 | 1.00 | TRPM8 (0.43) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL24540253 | 0.89 | TRPM8 (0.47) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL10155572 | 0.86 | TRPM8 (0.47) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL2628625 | 0.84 | TRPM8 (0.49) | TRPM8EPHX1ALDH1A1HPGDTAAR1 | |
| SCHEMBL24540793 | 0.83 | TRPM8 (0.47) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL24540369 | 0.83 | TRPM8 (0.47) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL29112383 | 0.83 | TRPM8 (0.47) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL24540494 | 0.83 | TRPM8 (0.47) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL24540387 | 0.83 | TRPM8 (0.48) | TRPM8EPHX1P2RX4SIGMAR1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083493-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083493-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | TRPC4, TRPC3, TRPC1 | TRPM8 7/4885EPHX1 2888/4885P2RX4 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.