Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653916 | 0.87 | HDAC4 (0.40) | KDM4ESMN1; SMN2MEN1KMT2AMAPK1 | |
| SCHEMBL18623686 | 0.81 | NPC1 (0.50) | KDM4ESMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL17951578 | 0.78 | EGFR (0.46) | EGFRSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL24540338 | 0.77 | THRB (0.43) | KDM4ESMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL352509 | 0.76 | MAPK1 (0.49) | EGFRSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL17653949 | 0.76 | MEN1 (0.43) | KDM4ESMN1; SMN2MEN1KMT2AMAPK1 | |
| SCHEMBL11645912 | 0.73 | EGFR (0.60) | EGFRSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL9610944 | 0.73 | MEN1 (0.44) | EGFRSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL27163685 | 0.72 | NOTUM (0.55) | KDM4ESMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL13200000 | 0.72 | MAPT (0.53) | KDM4ESMN1; SMN2HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133027-A1 | SUBSTITUTED CYCLOHEXANECARBOXAMIDES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-06-23 | — | — | WO | disclosed |