Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29717801 | 1.00 | RET (0.41) | RETDDR1MEN1KMT2APOLB | |
| SCHEMBL27197955 | 0.87 | ACHE (0.42) | MEN1KMT2APOLBCHEK1ACHE | |
| SCHEMBL27197957 | 0.87 | ACHE (0.42) | MEN1KMT2APOLBCHEK1ACHE | |
| SCHEMBL27197931 | 0.85 | DDR1 (0.40) | DDR1MEN1KMT2APOLBACHE | |
| SCHEMBL24542019 | 0.85 | DDR1 (0.40) | DDR1MEN1KMT2APOLBACHE | |
| SCHEMBL29717871 | 0.85 | DDR1 (0.40) | DDR1MEN1KMT2APOLBACHE | |
| SCHEMBL29718129 | 0.81 | JAK3 (0.49) | RETKMT2AMCHR1 | |
| SCHEMBL24541967 | 0.81 | JAK3 (0.49) | RETKMT2AMCHR1 | |
| SCHEMBL19734754 | 0.79 | BCHE (0.56) | DDR1MEN1KMT2AACHE | |
| SCHEMBL31140065 | 0.79 | ROCK2 (0.34) | DDR1MEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133064-A1 | FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN-MLL INTERACTION | BIOMEA FUSION, INC. (US) | 2022-06-23 | — | — | WO | disclosed |