Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBK | Q96KB5 | 6/20 | 0.45 |
| ▸ | PNP | P00491 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332973 | 0.83 | PBK (0.60) | PBKPNPADORA2AADORA2BADORA3 | |
| SCHEMBL2338271 | 0.80 | PDE4A (0.48) | PBKPNPADORA2AADORA2BADORA3 | |
| SCHEMBL402347 | 0.72 | KDM4E (0.64) | PBKPNPKDM4ESMN1; SMN2LMNA | |
| SCHEMBL15808078 | 0.70 | PDE4A (0.49) | ADORA2AADORA3ADORA1KDM4EPOLB | |
| SCHEMBL1581159 | 0.68 | PBK (0.49) | PBKKDM4ELMNAMEN1KMT2A | |
| SCHEMBL10867796 | 0.67 | — | — | |
| SCHEMBL10867790 | 0.67 | LMNA (0.48) | PBKPNPLMNATSHR | |
| SCHEMBL2454565 | 0.67 | ALDH1A1 (0.47) | ADORA2AADORA2BADORA1KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10411495 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL10411494 | 0.66 | PBK (0.47) | PBKLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364087-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | Oncotherapy Science, Inc. (JP) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010051085-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-06 | — | — | WO | disclosed |