Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2454697 | 0.89 | GSK3B (0.46) | MAPTPKMATMGSK3BPOLB | |
| SCHEMBL2808786 | 0.82 | GSK3B (0.50) | MAPTPKMGSK3BPOLBKDM4E | |
| SCHEMBL167302 | 0.79 | MAPT (0.51) | MAPTPKMATMPOLBCYP1A2 | |
| SCHEMBL1530035 | 0.78 | HPGD (0.39) | MAPTPKMATMGSK3BPOLB | |
| SCHEMBL16212681 | 0.78 | GSK3B (0.43) | MAPTPKMATMGSK3BPOLB | |
| SCHEMBL18430430 | 0.77 | KDM4E (0.49) | MAPTPKMGSK3BKDM4EGAA | |
| SCHEMBL24210733 | 0.77 | MAPT (0.43) | MAPTPKMATMPOLBCYP1A2 | |
| SCHEMBL1529989 | 0.77 | MAPT (0.46) | MAPTPKMATMPOLBCYP1A2 | |
| SCHEMBL16212934 | 0.76 | KDM4E (0.49) | MAPTPKMATMPOLBKDM4E | |
| SCHEMBL24210874 | 0.74 | MAPT (0.41) | MAPTPKMATMPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109195602-B | Symmetrical or semi-symmetrical compounds useful as immunomodulators | 上海齐鲁制药研究中心有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-104744446-B | Heteroaryl compound and its application in drug | 广东东阳光药业有限公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-109195602-A | Symmetrical or semi-symmetrical compounds useful as immunomodulators | 亚星国际公司 | 2019-01-11 | — | — | CN | disclosed |
| US-20140128571-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-05-08 | — | — | US | disclosed |
| US-20130165630-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2013-06-27 | — | — | US | disclosed |
| US-20120302780-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-11-29 | — | — | US | disclosed |
| US-20110237776-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302780-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | CBS, ARSA, SOD1 | MAPT 2812/4885PKM 2159/4885ATM 1038/4885 |
| US-20140128571-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | SOD1, CBS, ABCB7 | MAPT 2316/4885PKM 2422/4885ATM 1116/4885 |
| US-20110237776-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | SOD1, CBS, ABCB7 | MAPT 2316/4885PKM 2422/4885ATM 1116/4885 |
| US-20130165630-A1 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS | SOD1, CBS, ABCB7 | MAPT 2316/4885PKM 2422/4885ATM 1116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.