Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24548362 | 0.89 | CRBN (0.63) | CRBNDDB1POLB | |
| SCHEMBL30643548 | 0.86 | CRBN (0.60) | CRBNDDB1POLB | |
| SCHEMBL26641343 | 0.86 | CRBN (0.60) | CRBNDDB1POLB | |
| SCHEMBL25823294 | 0.85 | CRBN (0.63) | CRBNDDB1POLB | |
| SCHEMBL25822350 | 0.85 | CRBN (0.65) | CRBNDDB1POLB | |
| SCHEMBL24754171 | 0.83 | CRBN (0.66) | CRBNDDB1POLB | |
| SCHEMBL24754148 | 0.83 | CRBN (0.59) | CRBNDDB1POLB | |
| SCHEMBL26641131 | 0.81 | CRBN (0.54) | CRBNDDB1POLB | |
| SCHEMBL30643604 | 0.81 | CRBN (0.54) | CRBNDDB1POLB | |
| SCHEMBL26044005 | 0.79 | CRBN (0.47) | CRBNDDB1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133285-A1 | MOLECULES AND METHODS RELATED TO TREATMNET OF DISORDERS ASSOCIATED WITH JAK-2 SIGNALING DYSFUNCTION | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2022-06-23 | — | — | WO | disclosed |