SCHEMBL24548436

SCHEMBL24548436

O=C1c2cccc3c(N4CCOCC4)ccc(c23)C(=O)N1c1cccc(CCc2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H3 Q13133 2/20 0.57
KMT2A Q03164 11/20 0.56
MEN1 O00255 10/20 0.56
L3MBTL1 Q9Y468 6/20 0.56
HTT P42858 6/20 0.56
USP2 O75604 4/20 0.56
ALDH1A1 P00352 4/20 0.56
TLR9 Q9NR96 2/20 0.56
TNNI3 P19429 2/20 0.56
TNNT2 P45379 2/20 0.56
TNNC1 P63316 2/20 0.56
BRD1 O95696 1/20 0.54
TAF1 P21675 1/20 0.54
BRPF1 P55201 1/20 0.54
HDAC6 Q9UBN7 3/20 0.53
HDAC8 Q9BY41 2/20 0.53
HDAC10 Q969S8 1/20 0.53
LMNA P02545 5/20 0.52
HDAC3 O15379 3/20 0.50
HDAC1 Q13547 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6272272 0.80 HDAC6 (0.72) KMT2AMEN1L3MBTL1HTTUSP2
SCHEMBL7709378 0.78 MEN1 (0.54) KMT2AMEN1L3MBTL1HTTUSP2
SCHEMBL19404518 0.76 BRD1 (0.75) KMT2AMEN1L3MBTL1HTTUSP2
SCHEMBL16784368 0.75 MEN1 (0.68) KMT2AMEN1L3MBTL1HTTUSP2
SCHEMBL7712239 0.75 MEN1 (0.72) KMT2AMEN1L3MBTL1HTTUSP2
SCHEMBL6275389 0.74 KMT2A (0.62) KMT2AMEN1L3MBTL1HTTUSP2
SCHEMBL18648444 0.74 MEN1 (0.64) KMT2AMEN1L3MBTL1HTTUSP2
SCHEMBL28274860 0.74 KMT2A (0.62) KMT2AMEN1L3MBTL1HTTUSP2
SCHEMBL12660521 0.73 MEN1 (0.64) KMT2AMEN1L3MBTL1HTTUSP2
SCHEMBL28544782 0.73 HDAC6 (0.81) KMT2AMEN1L3MBTL1HTTUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220195199-A1 COLORED FUNCTIONALIZED [2,2] PARACYCLOPHANE AND COLORED CHEMICAL FILM NATIONAL TAIWAN UNIVERSITY (TW) 2022-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220195199-A1 COLORED FUNCTIONALIZED [2,2] PARACYCLOPHANE AND COLORED CHEMICAL FILM CYP1A2, CYP1A1, CYP1B1 NR1H3 610/4885KMT2A 1655/4885MEN1 3692/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.