Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 13/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | CRHBP | P24387 | 3/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703821 | 0.91 | MEN1 (0.58) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL7712190 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL6272272 | 0.83 | HDAC6 (0.72) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL7709336 | 0.81 | CYP1A2 (0.46) | MEN1KMT2ALMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL24548436 | 0.78 | NR1H3 (0.57) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL16784368 | 0.77 | MEN1 (0.68) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL7712239 | 0.77 | MEN1 (0.72) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL17620402 | 0.77 | MEN1 (0.53) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL22699960 | 0.77 | MEN1 (0.80) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL18648444 | 0.76 | MEN1 (0.64) | MEN1KMT2ALMNAHDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0939754-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998019648-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-05-14 | — | — | WO | disclosed |