Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 15/20 | 0.45 |
| ▸ | THRB | P10828 | 15/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 3/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24548665 | 0.88 | THRA (0.45) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL25673742 | 0.88 | THRA (0.54) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL25673739 | 0.84 | THRA (0.58) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL25240420 | 0.81 | THRA (0.49) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL24548722 | 0.81 | THRA (0.67) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL22660393 | 0.80 | THRA (0.66) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL24548661 | 0.77 | THRA (0.45) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL24548673 | 0.75 | THRA (0.43) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL23245118 | 0.70 | THRA (0.68) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL23245106 | 0.70 | THRA (0.68) | THRATHRBCYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022127779-A1 | SUBSTITUTED PYRIDAZINONE COMPOUND AND USE THEREOF | 山东第一医科大学(山东省医学科学院) | 2022-06-23 | — | — | WO | disclosed |