Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 12/20 | 0.45 |
| ▸ | THRB | P10828 | 12/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24548682 | 0.88 | THRA (0.45) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL25673742 | 0.88 | THRA (0.54) | THRATHRBCYP2C9CYP2C8NPC1 | |
| SCHEMBL24548731 | 0.81 | THRA (0.67) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL24548679 | 0.81 | THRA (0.49) | THRATHRBCYP2C9CYP2C8NPC1 | |
| SCHEMBL22660393 | 0.80 | THRA (0.66) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL24548672 | 0.79 | THRA (0.51) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL24548677 | 0.79 | THRA (0.47) | THRATHRBCYP2C9CYP2C8NPC1 | |
| SCHEMBL24548668 | 0.77 | THRA (0.44) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL25673739 | 0.76 | THRA (0.58) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL16703956 | 0.72 | L3MBTL1 (0.60) | THRATHRBCYP2C9CYP2C8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167091-A1 | SUBSTITUTED PYRIDAZINONE COMPOUND AND USE THEREOF | Shandong First Medical University & Shandong Academy Of Medical Sciences (CN) | 2023-06-01 | — | — | US | disclosed |
| WO-2022127779-A1 | SUBSTITUTED PYRIDAZINONE COMPOUND AND USE THEREOF | 山东第一医科大学(山东省医学科学院) | 2022-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167091-A1 | SUBSTITUTED PYRIDAZINONE COMPOUND AND USE THEREOF | THRB, TPO, TSHR | THRA 4/4885THRB 1/4885CYP2C9 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.