Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453774 | 0.86 | GPR119 (0.46) | GPR119EPHX2ALDH1A1 | |
| SCHEMBL2339452 | 0.86 | GPR119 (0.64) | GPR119HRH3 | |
| SCHEMBL2455123 | 0.82 | GPR119 (0.54) | GPR119MCHR1EPHX2 | |
| SCHEMBL2455772 | 0.81 | GPR119 (0.41) | GPR119MCHR1HRH3CHRM2ALDH1A1 | |
| SCHEMBL2453004 | 0.81 | GPR119 (0.52) | GPR119MCHR1EPHX2ALDH1A1 | |
| SCHEMBL4332781 | 0.81 | GPR119 (0.51) | GPR119HRH3 | |
| SCHEMBL2455221 | 0.79 | GPR119 (0.51) | GPR119MCHR1EPHX2 | |
| SCHEMBL2450082 | 0.77 | GPR119 (0.56) | GPR119MCHR1EPHX2KDM4EALDH1A1 | |
| SCHEMBL2456600 | 0.76 | GPR119 (0.58) | GPR119MCHR1HRH3EPHX2 | |
| SCHEMBL2453856 | 0.76 | GPR119 (0.56) | GPR119MCHR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170864-B1 | PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-14 | — | — | EP | claimed |