Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331353 | 0.86 | GPR119 (0.62) | GPR119 | |
| SCHEMBL2454882 | 0.86 | GPR119 (0.51) | GPR119EPHX2ALDH1A1 | |
| SCHEMBL2453004 | 0.85 | GPR119 (0.52) | GPR119EPHX2ALDH1A1HTT | |
| SCHEMBL2455123 | 0.83 | GPR119 (0.54) | GPR119EPHX2 | |
| SCHEMBL12334192 | 0.82 | IKBKB (0.48) | GPR119 | |
| SCHEMBL2455221 | 0.82 | GPR119 (0.51) | GPR119EPHX2 | |
| SCHEMBL2331486 | 0.77 | GPR119 (0.71) | GPR119 | |
| SCHEMBL2456600 | 0.76 | GPR119 (0.58) | GPR119EPHX2 | |
| SCHEMBL2452229 | 0.76 | GPR119 (0.58) | GPR119 | |
| SCHEMBL2453856 | 0.75 | GPR119 (0.56) | GPR119EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170864-B1 | PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-14 | — | — | EP | claimed |