Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 5/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457055 | 0.92 | AR (0.35) | MBOAT4P2RX7LMNAPKM | |
| SCHEMBL2456947 | 0.89 | DAO (0.33) | DAOLMNAPKM | |
| SCHEMBL2456758 | 0.87 | KDM4A (0.38) | MBOAT4P2RX7 | |
| SCHEMBL2454918 | 0.86 | PDE1B (0.34) | LMNAPKM | |
| SCHEMBL2454685 | 0.84 | DAO (0.36) | DAOP2RX7LMNAPKM | |
| SCHEMBL2455163 | 0.83 | ENPP1 (0.43) | DAOLMNAPKM | |
| SCHEMBL2457421 | 0.81 | ALKBH3 (0.36) | DAO | |
| SCHEMBL2455230 | 0.79 | PDE2A (0.38) | DAOMBOAT4 | |
| SCHEMBL2460223 | 0.79 | ENPP1 (0.43) | DAO | |
| SCHEMBL2460016 | 0.79 | CCR2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |